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Amyloid beta precursor protein-mRNA is expressed throughout cerebral vessel walls.
[hereditary cerebral hemorrhage with amyloidosis]
To
determine
the
presence
and
distribution
of
cerebrovascular
Abeta
production
we
investigated
amyloid
beta
precursor
protein
(
AbetaPP
)
-
mRNA
expression
by
RNA
in
situ
hybridization
in
patients
with
hereditary
cerebral
hemorrhage
with
amyloidosis
,
Dutch
type
,
Alzheimer
disease
and
controls
.
In
all
subjects
,
AbetaPP-mRNA
was
expressed
in
endothelial
cells
,
smooth
muscle
cells
,
adventitial
cells
and
brain
pericytes
and
/
or
perivascular
cells
.
Meningeal
cells
also
expressed
AbetaPP-mRNA
.
AbetaPP
was
detected
in
endothelial
cells
,
smooth
muscle
cells
and
adventitial
cells
.
The
demonstration
of
AbetaPP-mRNA
at
all
vascular
sites
where
amyloid
formation
can
occur
supports
an
important
contribution
of
locally
derived
Abeta
to
cerebrovascular
amyloidosis
.