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Insulin inhibits amyloid beta-induced cell death in cultured human brain pericytes.
[hereditary cerebral hemorrhage with amyloidosis]
Amyloid-
beta
(
Abeta
)
deposition
in
the
cerebral
arterial
and
capillary
walls
is
one
of
the
characteristics
of
Alzheimer
's
disease
and
hereditary
cerebral
hemorrhage
with
amyloidosis
-
Dutch
type
.
In
vitro
,
Abeta
1
-
40
,
carrying
the
"
Dutch
"
mutation
(
DAbeta
1
-
40
)
,
induced
reproducible
degeneration
of
cultured
human
brain
pericytes
(
HBP
)
,
by
forming
fibrils
at
the
cell
surface
.
Thus
,
this
culture
system
provides
an
useful
model
to
study
the
vascular
pathology
seen
in
Alzheimer
's
disease
.
In
this
study
,
we
used
this
model
to
investigate
the
effects
of
insulin
on
Abeta-induced
degeneration
of
HBP
,
as
it
has
been
mentioned
previously
that
insulin
is
able
to
protect
neurons
against
Abeta-induced
cell-death
.
The
toxic
effect
of
DAbeta
1
-
40
on
HBP
was
inhibited
by
insulin
in
a
dose-dependent
matter
.
Insulin
interacted
with
Abeta
and
inhibited
fibril
formation
of
Abeta
in
a
cell-free
assay
,
as
well
as
at
the
cell
surface
of
HBP
.
Our
data
indicate
that
the
formation
of
a
fibril
network
is
essential
for
Abeta-induced
cell
death
in
HBP
.
Additionally
,
insulin
may
be
involved
in
the
regulation
of
Abeta
fibrillization
in
AD
.
