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[The usefulness of platelet function evaluation in clinical practice].
[heparin-induced thrombocytopenia]
Platelets
play
a
pivotal
role
in
the
regulation
of
both
thrombosis
and
haemostasis
.
Functional
testing
of
platelet
response
has
been
exclusively
used
in
the
diagnosis
and
management
of
bleeding
disorders
.
Recent
advances
of
light
transmission
aggregometry
and
development
of
more
useful
devices
have
demonstrated
the
clinical
utility
to
enlarge
platelet
function
testing
in
patients
with
cardiovascular
disease
.
The
ex
vivo
measurement
of
residual
platelet
response
seems
,
with
some
assays
,
predictive
of
adverse
clinical
events
.
Still
a
debate
,
it
represents
an
emerging
area
of
interest
for
both
the
clinician
and
the
basic
scientist
.
Heparin-induced
thrombocytopenia
diagnosis
is
also
difficult
and
a
functional
assay
is
now
available
for
an
easier
and
rapid
method
to
rule
out
such
a
life-threatening
situation
.
This
review
article
will
describe
the
available
methods
of
measuring
platelet
response
and
will
discuss
both
the
limitations
and
emerging
data
supporting
the
role
of
platelet
function
studies
in
clinical
practice
.