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Postoperative thrombotic thrombocytopenic purpura.
[heparin-induced thrombocytopenia]
Thrombotic
thrombocytopenic
purpura
(
TTP
)
is
a
rare
,
life-threatening
disease
characterized
by
acute
episodes
of
thrombocytopenia
and
microangiopathic
hemolytic
anemia
occurring
due
to
platelet
and
von
Willebrand
factor
deposition
and
hyaline
thrombi
formation
in
arterioles
and
capillaries
throughout
the
body
,
which
results
in
organ
ischemia
.
TTP
can
be
idiopathic
or
secondary
,
and
there
are
several
causes
of
secondary
TTP
.
There
is
a
clinical
syndrome
resembling
TTP
that
occurs
after
surgical
procedures
,
so
-called
"
postoperative
TTP
"
(
pTTP
)
.
In
this
review
,
the
differential
diagnosis
,
pathogenesis
and
clinical
and
laboratory
features
of
pTTP
,
together
with
the
treatment
modalities
and
outcomes
of
the
patients
,
are
discussed
.
The
pTTP
is
a
diagnosis
of
exclusion
,
and
disseminated
intravascular
coagulation
,
heparin-induced
thrombocytopenia
and
medication-induced
effects
should
be
ruled
out
.
As
in
classical
TTP
,
patients
with
pTTP
should
be
diagnosed
and
treated
with
therapeutic
plasma
exchange
(
TPE
)
as
early
as
possible
to
reduce
their
morbidity
and
mortality
.
Although
rarely
seen
,
surgeons
and
physicians
of
all
specialties
should
be
alert
to
the
possibility
of
pTTP
,
and
since
pTTP
is
a
life-threatening
event
that
usually
can
be
treated
successfully
with
TPE
,
especially
when
diagnosed
early
in
its
course
,
it
is
critical
to
recognize
and
treat
pTTP
promptly
.
Diseases
Validation
Diseases presenting
"heparin-induced thrombocytopenia"
symptom
heparin-induced thrombocytopenia
This symptom has already been validated