Concomitant use of argatroban and warfarin during hemodialysis in heparin-induced thrombocytopenia.

[heparin-induced thrombocytopenia]

Objective and importance The use of argatroban during hemodialysis in a patient receiving warfarin is not established . We present a case of heparin-induced thrombocytopenia in a patient on hemodialytic therapy who successfully received argatroban concomitantly to warfarin during renal replacement therapy . Clinical presentation A 46 -year -old male patient with autosomal dominant polycystic kidney disease presented with heparin-induced thrombocytopenia (HIT ) arised during dialytic procedures . Intervention After the acute episode requiring argatroban and warfarin therapy , the patient continued to receive argatroban during the hemodialytic session concomitantly to warfarin . Conclusion The administration of argatroban in the dialytic circuit of a patient on oral anticoagulant therapy can be considered an effective and safe approach .