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Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: application to adrenomyeloneuropathy.
[adrenomyeloneuropathy]
Magnetization
transfer
(
MT
)
imaging
has
assessed
myelin
integrity
in
the
brain
and
spinal
cord
;
however
,
quantitative
MT
(
qMT
)
has
been
confined
to
the
brain
or
excised
tissue
.
We
characterized
spinal
cord
tissue
with
qMT
in
vivo
,
and
as
a
first
application
,
qMT-derived
metrics
were
examined
in
adults
with
the
genetic
disorder
Adrenomyeloneuropathy
(
AMN
)
.
AMN
is
a
progressive
disease
marked
by
demyelination
of
the
white
matter
tracts
of
the
cervical
spinal
cord
,
and
a
disease
in
which
conventional
MRI
has
been
limited
.
MT
data
were
acquired
at
1
.
5
Tesla
using
10
radiofrequency
offsets
at
one
power
in
the
cervical
cord
at
C
2
in
6
healthy
volunteers
and
9
AMN
patients
.
The
data
were
fit
to
a
two
-pool
MT
model
and
the
macromolecular
fraction
(
M
(
ob
)
)
,
macromolecular
transverse
relaxation
time
(
T
(
2
b
)
)
and
the
rate
of
MT
exchange
(
R
)
for
lateral
and
dorsal
column
white
matter
and
gray
matter
were
calculated
.
M
(
ob
)
for
healthy
volunteers
was
:
WM
=
13
.
9
+
/
-
2
.
3
%
,
GM
=
7
.
9
+
/
-
1
.
5
%
.
In
AMN
,
dorsal
column
M
(
ob
)
was
significantly
decreased
(
P
<
0
.
03
)
.
T
(
2
b
)
for
volunteers
was
:
9
+
/
-
2
micros
and
the
rate
of
MT
exchange
(
R
)
was
:
WM
=
56
+
/
-
11
Hz
,
GM
=
67
+
/
-
12
Hz
.
Neither
T
(
2
b
)
nor
R
showed
significant
differences
between
healthy
and
diseased
cords
.
Comparisons
are
made
between
qMT
,
and
conventional
MT
acquisitions
.
Diseases
Validation
Diseases presenting
"white matter"
symptom
22q11.2 deletion syndrome
adrenomyeloneuropathy
alexander disease
cadasil
canavan disease
classical phenylketonuria
cushing syndrome
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
homocystinuria without methylmalonic aciduria
kabuki syndrome
kallmann syndrome
krabbe disease
neonatal adrenoleukodystrophy
proteus syndrome
pyruvate dehydrogenase deficiency
sneddon syndrome
wiskott-aldrich syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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