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Heparin-induced thrombocytopenia after ICD-lead flushing.
[heparin-induced thrombocytopenia]
Heparin-induced
thrombocytopenia
(
HIT
)
is
a
potentially
life-threatening
prothrombotic
complication
following
heparin
administration
.
We
describe
a
patient
,
known
with
idiopathic
dilating
cardiomyopathy
,
presenting
nine
days
after
a
biventricular
ICD
implantation
with
dyspnoea
and
thrombocytopenia
.
Thirteen
days
after
administration
of
a
single
heparin
flush
during
ICD
implantation
,
the
patient
developed
venous
thrombosis
in
two
extremities
and
pulmonary
embolism
caused
by
HIT
.
HIT
is
the
development
of
thrombocytopenia
,
caused
by
IgG
antibodies
against
complexes
of
platelet
factor
4
and
heparin
,
leading
to
platelet
aggregation
.
HIT
may
be
accompanied
by
thrombosis
in
20
-
50
%
of
patients
and
untreated
mortality
rates
are
high
.
Once
HIT
is
suspected
,
heparin
should
be
replaced
by
an
alternative
anti-
factor
Xa
or
anti-
factor
II
therapy
.
Regardless
of
the
low
incidence
of
HIT
,
because
of
the
widespread
use
of
heparin
and
the
potentially
life-threatening
course
of
HIT
,
all
physicians
should
be
aware
of
it
.
Diseases
Validation
Diseases presenting
"the widespread use of heparin"
symptom
heparin-induced thrombocytopenia
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