Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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A randomized controlled comparison of flushing protocols in home care patients with peripherally inserted central catheters.
[heparin-induced thrombocytopenia]
Research
has
failed
to
demonstrate
an
optimal
flushing
solution
or
frequency
for
central
catheters
.
In
a
2002
study
of
50
000
home
care
patients
,
catheter
dysfunction
with
loss
of
patency
was
the
most
common
complication
and
occurred
in
29
%
of
the
peripherally
inserted
central
catheters
(
PICCs
)
tracked
.
With
the
advent
of
the
Affordable
Care
Act
and
the
promise
of
expanded
home
care
services
,
this
study
offers
evidence
as
to
a
preferred
flushing
protocol
to
prevent
catheter
patency
complications
for
home
infusion
patients
with
PICCs
.
T
his
prospective
,
randomized
,
1
-
way
,
single
-blinded
posttest
with
control
group
study
was
performed
to
compare
3
commonly
used
flushing
protocols
in
home
infusion
patients
with
PICCs
.
The
independent
variable
was
the
flushing
protocol
,
and
dependent
variables
included
the
development
of
patency-related
complications
and
other
significant
issues
such
as
sluggishness
,
occlusion
,
missed
medication
doses
,
catheter
replacement
,
additional
nursing
visits
,
and
the
use
of
alteplase
(
Cathflo
Activase
)
.
Each
of
the
study
groups
had
patients
who
experienced
1
or
more
patency-related
complications
.
Additional
factors
that
may
affect
catheter
function
,
including
patient
age
,
gender
,
diagnosis
,
therapy
type
,
frequency
of
catheter
use
,
catheter
brand
/
size
/
number
of
lumens
,
concomitant
use
of
anticoagulant
medications
,
and
whether
PICCs
were
used
for
routine
lab
testing
,
were
analyzed
,
and
no
statistical
significance
was
determined
.
Catheter
dwell
time
(
catheter
days
)
was
statistically
significant
(
p
=
.
003
,
confidence
interval
=
95
%
;
assuming
equal
variance
)
and
confirmed
the
assumption
that
the
longer
a
home
care
patient
's
catheter
was
in
place
,
the
more
complications
occurred
.
There
were
no
cases
of
heparin
allergy
,
heparin-induced
thrombocytopenia
,
or
line
infection
.
The
data
provide
some
evidence
to
support
the
elimination
of
heparin
flushing
in
home
care
patients
with
PICCs
,
although
data
in
the
saline-only
group
that
related
to
additional
registered
nurse
visits
to
assess
PICC
patency
and
the
use
of
alteplase
(
Cathflo
Activase
)
were
trending
toward
significance
because
this
group
experienced
a
higher
incidence
of
these
complications
than
both
the
heparin
groups
.
These
findings
should
not
be
translated
to
home
care
patients
with
cancer
or
pregnancy
diagnoses
because
these
populations
were
excluded
from
this
study
.
More
studies
of
this
topic
area
should
be
initiated
.
Please
see
video
abstract
,
Supplemental
Digital
Content
1
,
for
more
information
(
http
:
/
/
links
.
lww
.
com
/
JIN
/
A
3
)
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated