Thrombotic microangiopathies (TTP, HUS, HELLP).

[heparin-induced thrombocytopenia]

Thrombocytopenia , strictly defined as a platelet count less than 150 ,000 , is common in the emergency department . Recognition , diagnostic investigation , and proper disposition of a thrombocytopenic patient are imperative . One group of disorders leading to thrombocytopenia is the thrombotic microangiopathies , hallmarked by platelet destruction . These thrombotic microangiopathies include thrombotic thrombocytopenic purpura (TTP ), hemolytic uremic syndrome (HUS ) and hemolysis , elevated liver enzyme levels , low platelet count (HELLP ), which should be distinguished from similar disease processes such as immune thrombocytopenia (ITP ), disseminated intravascular coagulation (DIC ) and heparin induced thrombocytopenia (HIT ). In this article , clinical presentations , pathophysiology , diagnostic workup , management plans , complications , and dispositions are addressed for this complex group of platelet disorders .

Diseases
Validation

Diseases presenting "thrombocytopenia" symptom

22q11.2 deletion syndrome

adrenomyeloneuropathy

dedifferentiated liposarcoma

erythropoietic protoporphyria

esophageal adenocarcinoma

heparin-induced thrombocytopenia

hodgkin lymphoma, classical

holt-oram syndrome

homocystinuria without methylmalonic aciduria

liposarcoma

malignant atrophic papulosis

monosomy 21

oculocutaneous albinism

scrub typhus

sneddon syndrome

typhoid

waldenström macroglobulinemia

wiskott-aldrich syndrome

This symptom has already been validated