Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Update on argatroban for the prophylaxis and treatment of heparin-induced thrombocytopenia type II.
[heparin-induced thrombocytopenia]
Heparin-induced
thrombocytopenia
(
HIT
)
is
a
rare
but
potentially
severe
complication
of
heparin
therapy
that
is
strongly
associated
with
venous
and
arterial
thrombosis
(
HIT
and
thrombosis
syndrome
,
HITTS
)
,
which
requires
urgent
detection
and
treatment
with
a
nonheparin
anticoagulant
.
Argatroban
,
a
synthetic
direct
thrombin
inhibitor
,
is
indicated
for
the
treatment
and
prophylaxis
of
thrombosis
in
patients
with
HIT
,
including
those
undergoing
percutaneous
coronary
intervention
.
Argatroban
has
a
relatively
short
elimination
half
-life
of
approximately
45
minutes
,
which
is
predominantly
performed
via
hepatic
metabolism
.
It
is
derived
from
L-
arginine
that
selectively
and
reversibly
inhibits
thrombin
,
both
clot-bound
and
free
,
at
the
catalytic
site
.
Argatroban
anticoagulation
has
been
systematically
studied
in
patients
with
HIT
and
HITTS
and
proved
to
be
a
safe
and
effective
agent
for
this
indication
.
The
current
review
presents
the
pharmacology
of
argatroban
,
data
regarding
monitoring
of
the
agent
,
and
an
overview
of
the
results
of
the
major
clinical
trials
assessing
argatroban
anticoagulation
in
HIT
patients
.
Additionally
,
data
from
recent
clinical
trials
with
argatroban
use
in
more
special
indications
such
as
in
percutaneous
coronary
intervention
,
liver
dysfunction
,
renal
replacement
therapy
,
and
intensive
care
medicine
,
are
reviewed
.
The
approved
initial
dosage
of
argatroban
for
adults
with
HIT
or
HITTS
is
2
μg
/
kg
/
minute
for
patients
with
normal
hepatic
function
and
0
.
5
μg
/
kg
/
minute
for
patients
with
hepatic
dysfunction
.
There
is
evidence
that
a
reduced
initial
dose
may
also
be
advisable
for
patients
with
heart
failure
,
multiple
organ
dysfunction
,
severe
anasarca
,
or
after
cardiac
surgery
.
Given
this
information
,
argatroban
can
be
effectively
used
in
treating
HIT
with
monitoring
of
activated
partial
thromboplastin
time
.
Diseases
Validation
Diseases presenting
"and intensive care medicine"
symptom
heparin-induced thrombocytopenia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom