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Harlequin ichthyosis in two greater kudu (Tragelaphus strepsiceros).
[harlequin ichthyosis]
Two
greater
kudu
calves
(
Tragelaphus
strepsiceros
)
born
7
years
apart
were
found
with
fissures
and
thickened
,
scaly
,
cutaneous
plates
covering
over
80
%
of
their
bodies
.
One
was
dead
at
presentation
,
and
the
other
was
euthanized
shortly
after
birth
.
Both
animals
shared
a
common
sire
.
On
necropsy
,
chemosis
,
ectropion
,
eclabium
,
and
bilateral
valgus
deformities
of
the
tarsal
joints
were
observed
in
one
calf
,
presumed
to
be
secondary
to
the
plates
restricting
normal
fetal
development
.
The
principal
microscopic
lesion
was
severe
lamellar
orthokeratosis
,
with
focal
mild
parakeratosis
.
Ultrastructural
epidermal
lesions
included
the
absence
of
normal
lamellar
granules
,
large
dilated
endoplasmic
reticulum
,
and
abnormal
retention
of
organelles
and
vesicles
.
Gross
,
histopathologic
,
and
electron
microscopic
findings
in
both
kudu
calves
were
consistent
with
those
of
harlequin
ichthyosis
,
a
rare
dermatosis
of
humans
believed
to
have
an
autosomal
recessive
inheritance
pattern
.
The
underlying
genetic
and
molecular
abnormality
and
heritability
of
this
condition
in
this
greater
kudu
herd
were
not
determined
.
Diseases
Validation
Diseases presenting
"chemosis"
symptom
harlequin ichthyosis
lamellar ichthyosis
This symptom has already been validated