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Harlequin ichthyosis: ABCA12 mutations underlie defective lipid transport, reduced protease regulation and skin-barrier dysfunction.
[harlequin ichthyosis]
Harlequin
ichthyosis
(
HI
)
is
a
devastating
autosomal
recessive
congenital
skin
disease
.
It
has
been
vital
to
elucidate
the
biological
importance
of
the
protein
ABCA
12
in
skin
-barrier
permeability
,
following
the
discovery
that
ABCA
12
gene
mutations
can
result
in
this
rare
disease
.
ATP-binding
cassette
transporter
A
12
(
ABCA
12
)
is
a
member
of
the
subfamily
of
ATP-binding
cassette
transporters
and
functions
to
transport
lipid
glucosylceramides
(
GlcCer
)
to
the
extracellular
space
through
lamellar
granules
(
LGs
)
.
GlcCer
are
hydrolysed
into
hydroxyceramides
extracellularly
and
constitute
a
portion
of
the
extracellular
lamellar
membrane
,
lipid
envelope
and
lamellar
granules
.
In
HI
skin
,
loss
of
function
of
ABCA
12
due
to
null
mutations
results
in
impaired
lipid
lamellar
membrane
formation
in
the
cornified
layer
,
leading
to
defective
permeability
of
the
skin
barrier
.
In
addition
,
abnormal
lamellar
granule
formation
(
distorted
shape
,
reduced
in
number
or
absent
)
could
further
cause
aberrant
production
of
LG
-associated
desquamation
enzymes
,
which
are
likely
to
contribute
to
the
impaired
skin
barrier
in
HI
.
This
article
reviews
current
opinions
on
the
patho-mechanisms
of
ABCA
12
action
in
HI
and
potential
therapeutic
interventions
based
on
targeted
molecular
therapy
and
gene
therapy
strategies
.
Diseases
Validation
Diseases presenting
"targeted molecular therapy and gene therapy strategies"
symptom
harlequin ichthyosis
lamellar ichthyosis
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