Harlequin ichthyosis: Case report.

[harlequin ichthyosis]

Harlequin fetus is a rare and the most severe form of the congenital ichthyosis with an autosomal recessive inheritance . Incidence of the disease is nearly 1 in 3 ,00 ,000 live births . The disease might be lethal at birth and the affected babies are often premature . Harlequin ichthyosis (HI ) is marked by severe keratinized and alligator-like horned skin . The present study reports a new case with HI and adds to the collective knowledge of this rare skin disorder . HI has been linked to mutation in the ABCA 12 gene ; therefore , genetic counseling and mutation screening of this gene should be considered .