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Pathological features of salivary gland cysts in a Shiba dog with GM1 gangliosidosis: a possible misdiagnosis as malignancy.
[gm1 gangliosidosis]
Salivary
gland
cysts
are
often
concurrent
with
GM
1
gangliosidosis
in
Shiba
dogs
.
Although
the
etiology
is
unknown
,
these
cysts
may
be
misdiagnosed
as
malignant
due
to
the
accumulation
of
foamy
cells
.
The
present
study
investigated
the
cytological
,
histopathological
,
immunohistochemical
and
electron
microscopic
characteristics
of
salivary
gland
cysts
in
a
Shiba
dog
affected
with
GM
1
gangliosidosis
.
The
salivary
gland
masses
were
surgically
enucleated
and
examined
clinicopathologically
and
pathologically
in
a
7
-
month
-old
Shiba
dog
with
GM
1
gangliosidosis
.
Many
large
cells
with
rich
cytoplasm
including
vacuoles
of
various
sizes
,
i
.
e
.
,
foamy
cells
,
were
observed
in
stamp
smears
from
the
cut-surface
of
the
masses
and
histopathologically
in
major
parts
of
the
cyst
wall
.
Some
of
these
foamy
cells
presented
features
similar
to
a
spider-web
appearance
.
The
foamy
cells
were
confirmed
to
have
originated
from
macrophages
based
on
marked
immunohistochemical
expression
of
vimentin
,
HLA-
DR
,
lysozyme
and
Iba
1
.
An
ultrastructural
study
demonstrated
electron-
dense
vesicular
structures
in
the
vacuolated
cells
.
Therefore
,
the
masses
were
diagnosed
pathologically
as
benign
salivary
gland
cysts
with
accumulation
of
foamy
cells
.
In
conclusion
,
the
histopathological
features
of
the
salivary
gland
cysts
in
this
Shiba
dog
were
similar
to
those
of
lipoma
and
/
or
liposarcoma
.
In
such
cases
,
immunohistochemical
and
ultrastructural
examinations
were
useful
in
the
differential
diagnosis
.
Practitioners
,
clinical
pathologists
and
pathologists
should
take
GM
1
gangliosidosis
into
consideration
when
they
encounter
salivary
gland
cysts
in
Shiba
dogs
.
Diseases
Validation
Diseases presenting
"benign salivary gland cysts"
symptom
gm1 gangliosidosis
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