Lysosomal disorders associated with leukoencephalopathy.

[gm1 gangliosidosis]

Metachromatic leukodystrophy and Krabbe 's disease are among the most widely recognized causes of leukodystrophy . However , white matter changes have been described in several other lysosomal storage disorders . These conditions are summarized and those associated with hypomyelination are reviewed in more detail .