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Identification of Bangladeshi domestic cats with GM1 gangliosidosis caused by the c.1448G>C mutation of the feline GLB1 gene: case study.
[gm1 gangliosidosis]
GM
1
gangliosidosis
is
a
fatal
,
progressive
neurodegenerative
lysosomal
storage
disease
caused
by
mutations
in
the
β-galactosidase
(
GLB
1
)
gene
.
In
feline
GM
1
gangliosidosis
,
a
pathogenic
mutation
(
c
.
1448
G
>
C
)
in
the
feline
GLB
1
gene
was
identified
in
Siamese
cats
in
the
United
States
and
Japan
and
in
Korat
cats
in
Western
countries
.
The
present
study
found
the
homozygous
c
.
1448
G
>
C
mutation
in
2
apparent
littermate
native
kittens
in
Bangladesh
that
were
exhibiting
neurological
signs
.
This
is
the
first
identification
of
GM
1
gangliosidosis
in
native
domestic
cats
in
Southeast
Asia
.
This
pathogenic
mutation
seems
to
have
been
present
in
the
domestic
cat
population
in
the
Siamese
region
and
may
have
been
transferred
to
pure
breeds
such
as
Siamese
and
Korat
cats
originating
in
this
region
.
Diseases
Validation
Diseases presenting
"native domestic cats"
symptom
gm1 gangliosidosis
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