Rare Diseases Symptoms Automatic Extraction
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Disseminated Histoplasma capsulatum infection presenting with panniculitis and focal myositis in rheumatoid arthritis treated with etanercept.
[focal myositis]
We
report
the
case
of
a
patient
with
rheumatoid
arthritis
(
RA
)
on
etanercept
who
presented
with
panniculitis
and
focal
myositis
as
manifestations
of
disseminated
histoplasmosis
.
Systematic
search
of
the
literature
showed
11
additional
case
reports
of
disseminated
histoplasmosis
with
tumour
necrosis
factor
-alpha
(
TNFalpha
)
blockade
therapy
(
infliximab
,
n
=
8
;
etanercept
,
n
=
3
)
.
Although
disseminated
histoplasmosis
may
manifest
with
classical
symptoms
of
fever
and
respiratory
complaints
,
it
may
also
present
atypically
,
such
as
with
panniculitis
and
focal
myositis
.
This
review
illustrates
and
emphasizes
the
importance
of
being
highly
suspicious
for
infection
,
including
by
opportunistic
organisms
,
and
to
exclude
such
process
in
patients
treated
with
a
TNFalpha
inhibitor
when
faced
with
unusual
complications
,
even
when
an
alternative
aetiology
appears
plausible
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated
