Idiopathic uveitis and familial mediterranean Fever: is there any relationship?

[familial mediterranean fever]

Introduction . Familial Mediterranean fever (FMF ) is an auto-inflammatory disease characterized by attacks of fever and polyserositis . FMF is often associated with other autoimmune diseases such as rheumatoid arthritis , polyarteritis nodosa (PAN ), and Behcet . Uveitis is an inflammatory process caused by underlying infectious and inflammatory disorders . This study investigates the probable relationship between idiopathic uveitis and FMF . Methods . Patients with idiopathic uveitis were analyzed for the 12 most common MEFV mutations (P 369 S , F 479 L , M 680 I (G /C ), M 680 I (G /A ), I 692 del , M 694 V , M 694 I , K 695 R , V 726 A , A 744 S , R 761 H , E 148 Q ) by a reverse hybridization assay (FMF StripAssay ,Vienna lab ,Vienna , Austria ). Results . 12 patients with idiopathic uveitis were enrolled in this study . 10 of them were female . The youngest patient was a 7 -year -old child and the oldest was 57 . The most common complaints of patients were blurred vision and then eye redness . One patient was heterozygous for R 761 H . Genetic analysis of the 12 most common MEFV mutations in the patients with idiopathic uveitis didnot have any positive results . Conclusion . According to the analysis of the 12 most common MEFV gene mutations , FMF is not an underlying cause of idiopathic uveitis . On the other hand , uveitis merely could not be the first presentation of FMF .

Diseases
Validation

Diseases presenting "fever" symptom

22q11.2 deletion syndrome

acute rheumatic fever

alexander disease

allergic bronchopulmonary aspergillosis

canavan disease

carcinoma of the gallbladder

child syndrome

congenital toxoplasmosis

cushing syndrome

cystinuria

dracunculiasis

erdheim-chester disease

esophageal adenocarcinoma

esophageal carcinoma

familial mediterranean fever

focal myositis

hodgkin lymphoma, classical

lamellar ichthyosis

legionellosis

locked-in syndrome

malignant atrophic papulosis

neonatal adrenoleukodystrophy

neuralgic amyotrophy

oculocutaneous albinism

papillon-lefèvre syndrome

pyomyositis

pyruvate dehydrogenase deficiency

scrub typhus

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

typhoid

waldenström macroglobulinemia

wolf-hirschhorn syndrome

This symptom has already been validated