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A random Abstract
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Neutrophil-Lymphocyte Ratio in Patients With Familial Mediterranean Fever.
[familial mediterranean fever]
Blood
neutrophil-
to
-lymphocyte
(
N
/
L
)
ratio
is
an
indicator
of
the
overall
inflammatory
status
of
the
body
,
and
an
alteration
in
N
/
L
ratio
may
be
found
in
patients
with
familial
Mediterranean
fever
(
FMF
)
.
The
aim
of
this
study
was
to
investigate
the
interrelationship
between
N
/
L
ratio
and
FMF
.
O
ne
hundred
and
fifteen
patients
and
controls
were
enrolled
in
the
study
.
The
cases
in
the
study
were
categorized
as
FMF
with
attack
,
FMF
with
attack-free
period
,
and
controls
.
The
neutrophil
and
lymphocyte
counts
were
recorded
,
and
the
N
/
L
ratio
was
calculated
from
these
parameters
.
All
patients
were
diagnosed
according
to
Tel
Hashomer
criteria
.
A
total
of
79
FMF
patients
were
included
in
the
study
and
all
subjects
were
receiving
colchicine
treatment
at
the
time
.
The
serum
N
/
L
ratios
of
active
patients
were
significantly
higher
than
those
of
attack-free
FMF
patients
and
controls
(
P
<
0
.
001
)
.
The
optimum
N
/
L
ratio
cut-off
point
for
active
FMF
was
2
.
63
with
sensitivity
,
specificity
,
positive
predictive
value
,
and
negative
predictive
value
of
0
.
62
(
0
.
41
-
0
.
80
)
,
0
.
85
(
0
.
72
-
0
.
93
)
,
0
.
67
(
0
.
44
-
0
.
85
)
,
and
0
.
82
(
0
.
69
-
0
.
91
)
,
respectively
.
The
overall
accuracy
of
the
N
/
L
ratio
in
determination
of
FMF
patients
during
attack
was
71
%
.
Our
results
demonstrate
that
N
/
L
ratio
is
higher
in
patients
with
active
FMF
compared
with
FMF
patients
in
remission
and
controls
,
and
a
cut-off
value
of
2
.
63
can
be
used
to
identify
patients
with
active
FMF
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated