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Endothelial function in patients with familial Mediterranean fever-related amyloidosis and association with cardiovascular events.
[familial mediterranean fever]
Secondary
amyloidosis
is
the
most
important
complication
of
FMF
and
endothelial
function
is
more
severely
impaired
.
Elevated
asymmetric
dimethyl
arginine
(
ADMA
)
may
mediate
the
excess
cardiovascular
disease
(
CVD
)
risk
of
this
group
.
We
aimed
to
compare
endothelial
function
characteristics
,
including
ADMA
,
in
patients
with
FMF
-related
amyloidosis
and
primary
glomerulopathies
and
to
define
risk
factors
for
a
CVD
event
.
We
undertook
a
cross-sectional
study
with
prospective
follow-up
including
consecutive
patients
with
FMF
-related
amyloidosis
(
n
=
98
)
or
other
non-diabetic
glomerulopathies
(
n
=
102
)
.
All
patients
had
nephrotic-range
proteinuria
and
normal
glomerular
filtration
rate
.
Flow-mediated
dilatation
(
FMD
)
was
assessed
and
ADMA
levels
,
CRP
and
pentraxin
3
(
PTX
3
)
were
determined
.
Patients
were
followed
for
cardiovascular
events
.
Amyloidosis
patients
secondary
to
FMF
showed
higher
levels
of
ADMA
,
CRP
and
PTX
3
and
lower
FMD
as
compared
with
patients
with
other
glomerulopathies
.
Cardiovascular
events
(
n
=
54
)
were
registered
during
3
years
of
follow-up
.
Increased
ADMA
levels
and
lower
FMD
were
observed
in
patients
with
cardiovascular
risk
in
both
groups
,
but
especially
in
individuals
with
amyloidosis
.
Patients
with
FMF
-related
amyloidosis
have
increased
CVD
event
risk
,
probably
related
to
the
high
ADMA
levels
,
elevated
inflammatory
markers
and
decreased
FMD
measures
observed
in
these
patients
.
Diseases
Validation
Diseases presenting
"elevated inflammatory markers"
symptom
acute rheumatic fever
familial mediterranean fever
malignant atrophic papulosis
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