Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Assessment of Thyroid Disorders and Autoimmunity in Patients with Rheumatic Diseases.
[familial mediterranean fever]
We
investigated
whether
there
was
a
significant
increase
in
thyroid
autoimmunity
,
and
disorders
in
patients
with
rheumatic
diseases
(
RDs
)
.
We
enrolled
201
patients
with
RDs
(
41
with
ankylosing
spondylitis
,
15
with
systemic
lupus
erythematosus
,
80
with
rheumatoid
arthritis
[
RA
]
,
65
with
familial
Mediterranean
fever
)
,
and
122
healthy
controls
.
Serum
levels
of
thyroid
-stimulating
hormone
(
TSH
)
,
free
triiodothyronine
(
fT
3
)
,
free
thyroxine
(
fT
4
)
,
C-
reactive
protein
,
and
thyroid
autoantibodies
(
anti-
thyroglobulin
and
anti-
thyroid
peroxidase
)
were
measured
in
all
participants
.
There
were
no
significant
differences
between
the
ages
of
the
patients
and
controls
.
The
mean
TSH
values
of
the
patients
with
RDs
and
the
controls
were
3
.
1
±
2
.
68
mIU
/
L
and
1
.
9
±
0
.
83
mIU
/
L
,
respectively
(
P
=
0
.
004
)
.
The
mean
fT
4
value
of
the
patients
with
RDs
was
1
.
43
±
0
.
67
ng
/
dL
whereas
that
of
the
controls
was
1
.
58
±
0
.
68
ng
/
dL
(
P
<
0
.
001
)
.
Subclinical
hypothyroidism
was
detected
in
24
patients
with
RDs
.
Thyroid
antibodies
were
detected
in
16
of
201
(
8
%
)
patients
with
RDs
.
Three
of
these
patients
had
subclinical
hypothyroidism
,
while
the
others
were
euthyroid
.
Thyroid
autoantibodies
were
significantly
higher
in
patients
with
RDs
(
P
<
0
.
001
)
.
Additionally
,
thyroid
disorders
were
observed
more
frequently
in
patients
with
RDs
than
in
the
healthy
controls
.
Based
on
our
findings
,
we
recommend
that
thyroid
function
tests
should
better
be
included
in
the
clinical
evaluation
of
patients
with
RDs
.
Diseases
Validation
Diseases presenting
"hypothyroidism"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
adrenomyeloneuropathy
alpha-thalassemia
aromatase deficiency
congenital adrenal hyperplasia
cowden syndrome
cushing syndrome
familial mediterranean fever
gm1 gangliosidosis
harlequin ichthyosis
hirschsprung disease
inclusion body myositis
kallmann syndrome
pendred syndrome
proteus syndrome
pyruvate dehydrogenase deficiency
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated