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A random Abstract
Our Project
Our Team
Assessment of Thyroid Disorders and Autoimmunity in Patients with Rheumatic Diseases.
[familial mediterranean fever]
We
investigated
whether
there
was
a
significant
increase
in
thyroid
autoimmunity
,
and
disorders
in
patients
with
rheumatic
diseases
(
RDs
)
.
We
enrolled
201
patients
with
RDs
(
41
with
ankylosing
spondylitis
,
15
with
systemic
lupus
erythematosus
,
80
with
rheumatoid
arthritis
[
RA
]
,
65
with
familial
Mediterranean
fever
)
,
and
122
healthy
controls
.
Serum
levels
of
thyroid
-stimulating
hormone
(
TSH
)
,
free
triiodothyronine
(
fT
3
)
,
free
thyroxine
(
fT
4
)
,
C-
reactive
protein
,
and
thyroid
autoantibodies
(
anti-
thyroglobulin
and
anti-
thyroid
peroxidase
)
were
measured
in
all
participants
.
There
were
no
significant
differences
between
the
ages
of
the
patients
and
controls
.
The
mean
TSH
values
of
the
patients
with
RDs
and
the
controls
were
3
.
1
±
2
.
68
mIU
/
L
and
1
.
9
±
0
.
83
mIU
/
L
,
respectively
(
P
=
0
.
004
)
.
The
mean
fT
4
value
of
the
patients
with
RDs
was
1
.
43
±
0
.
67
ng
/
dL
whereas
that
of
the
controls
was
1
.
58
±
0
.
68
ng
/
dL
(
P
<
0
.
001
)
.
Subclinical
hypothyroidism
was
detected
in
24
patients
with
RDs
.
Thyroid
antibodies
were
detected
in
16
of
201
(
8
%
)
patients
with
RDs
.
Three
of
these
patients
had
subclinical
hypothyroidism
,
while
the
others
were
euthyroid
.
Thyroid
autoantibodies
were
significantly
higher
in
patients
with
RDs
(
P
<
0
.
001
)
.
Additionally
,
thyroid
disorders
were
observed
more
frequently
in
patients
with
RDs
than
in
the
healthy
controls
.
Based
on
our
findings
,
we
recommend
that
thyroid
function
tests
should
better
be
included
in
the
clinical
evaluation
of
patients
with
RDs
.
Diseases
Validation
Diseases presenting
"autoimmunity"
symptom
acute rheumatic fever
benign recurrent intrahepatic cholestasis
epidermolysis bullosa simplex
familial mediterranean fever
inclusion body myositis
omenn syndrome
wiskott-aldrich syndrome
This symptom has already been validated