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A random Abstract
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The hereditary autoinflammatory disorders uncovered.
[familial mediterranean fever]
There
is
a
thriving
interest
in
the
field
of
hereditary
autoinflammatory
disorders
(
HAID
)
,
a
gamut
of
heterogeneous
conditions
deriving
from
an
aberrant
orchestration
of
innate
immunity
,
unified
by
the
common
feature
of
seemingly
unprovoked
inflammation
,
which
might
be
systemic
or
occur
in
localized
niches
of
the
organism
.
Recurrent
fever
and
episodic
inflammation
in
the
joints
,
serosal
membranes
,
skin
,
gut
,
and
other
organs
are
the
common
denominator
of
HAID
.
Mutations
in
the
inflammasome-related
genes
have
been
associated
with
different
HAID
,
showing
the
intimate
link
existing
between
interleukin-
1
(
IL
-
1
)
-
structured
inflammasome
and
their
pathogenesis
.
Differential
diagnosis
of
HAID
can
be
challenging
,
as
there
are
no
universally
accepted
diagnostic
protocols
,
and
near
half
of
patients
may
remain
without
any
genetic
abnormality
identified
.
The
use
of
IL
-
1
-
antagonists
has
been
associated
with
beneficial
effects
in
a
large
number
of
HAID
associated
with
excessive
IL
-
1
signalling
,
such
as
cryopyrin-associated
periodic
syndromes
,
familial
Mediterranean
fever
,
and
deficiency
of
IL
-
1
receptor
antagonist
.
This
review
will
discuss
about
the
key-clues
of
HAID
which
might
guide
for
an
early
recognition
and
drive
decisions
for
treatment
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated