The coincidence of familial mediterranean Fever and hypereosinophilia in a patient with hereditary elliptocytosis.

[familial mediterranean fever]

Familial Mediterranean fever (FMF ) is a genetic disease with autosomal inheritance characterized by recurrent fever , abdominal pain , and serositis attacks . It is relatively common in the races and ethnical groups around Mediterranean Sea (Sephardic Jews , Armenians , Turks and Arabians ). Hereditary elliptocytosis (HE ) is common genetic defect of the red blood cell membrane skeleton . Spectrin mutations are the predominant causes of HE . Hypereosinophilia is defined as a number of eosinophil granulocytes equal or greater than 0 .5 × 10 (9 )/L of circulating blood . The main causes are allergies and parasitic infections . This case report describes a Turkish female HE patient who presented with FMF and hypereosinophilia . Genetic analysis revealed heterozygous mutation in exon 10 of the MEFV gene (V 726 A ). The patient was successfully treated with colchicine and steroid treatment at 3 -month follow-up . To the best of our knowledge , this is the first report of association between FMF , HE , and hypereosinophilia .

Diseases
Validation

Diseases presenting "abdominal pain" symptom

22q11.2 deletion syndrome

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

carcinoma of the gallbladder

child syndrome

cholangiocarcinoma

congenital diaphragmatic hernia

cushing syndrome

cutaneous mastocytosis

cystinuria

dedifferentiated liposarcoma

erdheim-chester disease

erythropoietic protoporphyria

fabry disease

familial hypocalciuric hypercalcemia

familial mediterranean fever

focal myositis

liposarcoma

lymphangioleiomyomatosis

malignant atrophic papulosis

pleomorphic liposarcoma

primary effusion lymphoma

primary hyperoxaluria type 1

proteus syndrome

scrub typhus

sneddon syndrome

systemic capillary leak syndrome

typhoid

von hippel-lindau disease

well-differentiated liposarcoma

This symptom has already been validated