Intrauterine device may trigger typical attacks of familial Mediterranean fever: a case report.

[familial mediterranean fever]

Familial Mediterranean fever (FMF ) is an autosomal recessive disorder characterized by episodic , recurrent , self-limited attacks of fever and serositis (sterile peritonitis , pleuritis , arthritis , etc ). The insufficiency in restriction of mild inflammation contributes this consequence in FMF .Intrauterine devices (IUDs ) have been widely used in the world for contraception by gynecologists as an effective and safe method . Herein , we present a woman with FMF as the first case , whose attacks were triggered by copper-containing IUD . Our hypothesis in the present case was that sterile mild inflammation in the uterus caused by copper-containing IUD may be the initial source of systemic inflammatory response .In our opinion , clinicians should consider that the copper-containing IUDs may be another cause of FMF attacks in women using this contraceptive method .