Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Forearm bone mineral density in familial hypocalciuric hypercalcemia and primary hyperparathyroidism: a comparative study.
[familial hypocalciuric hypercalcemia]
Studies
have
shown
that
cancellous
bone
is
relatively
preserved
in
primary
hyperparathyroidism
(
PHPT
)
,
whereas
bone
loss
is
seen
in
cortical
bone
.
Familial
hypocalciuric
hypercalcemia
(
FHH
)
patients
seem
to
preserve
bone
mineral
in
spite
of
hypercalcemia
and
often
elevated
plasma
parathyroid
hormone
(
PTH
)
.
The
objective
of
this
study
was
to
compare
total
and
regional
forearm
bone
mineral
density
(
BMD
)
in
patients
with
PHPT
and
FHH
and
to
examine
if
differences
can
be
used
to
separate
the
two
disorders
.
We
included
63
FHH
,
and
121
PHPT
patients
in
a
cross-sectional
study
.
We
performed
dual-energy
X-
ray
absorptiometry
scans
of
the
forearm
,
hip
and
lumbar
spine
and
measured
a
number
of
biochemical
variables
.
PTH
patients
had
significantly
lower
Z-
scores
in
all
parts
of
the
forearm
compared
to
FHH
.
This
was
also
the
case
after
adjustment
for
body
mass
index
.
When
stratifying
for
age
,
gender
and
PTH
,
T
-
scores
were
still
significantly
lower
in
PHPT
patients
than
in
FHH
patients
at
the
total
,
the
mid
and
the
ultradistal
forearm
,
but
not
at
the
proximal
1
/
3
forearm
.
In
a
multiple
regression
analysis
BMD
Z-
score
was
lower
in
PHPT
compared
to
FHH
at
the
total
forearm
,
the
mid
forearm
and
the
ultradistal
forearm
but
not
the
proximal
forearm
when
adjusting
for
biochemical
variables
including
PTH
,
1
,
25
(
OH
)
(
2
)
D
and
Ca
(
2
+
)
.
These
observations
support
that
inactivating
mutations
in
the
CASR
gene
in
bone
cells
in
FHH
may
protect
against
forearm
bone
loss
.
Differences
between
the
two
groups
in
total
or
regional
forearm
BMD
were
inferior
to
the
calcium
/
creatinine
clearance
ratio
as
a
diagnostic
tool
to
separate
FHH
from
PHPT
.
Diseases
Validation
Diseases presenting
"bone mineral density"
symptom
achondroplasia
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
aromatase deficiency
congenital adrenal hyperplasia
cushing syndrome
dentinogenesis imperfecta
erythropoietic protoporphyria
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
kallmann syndrome
lamellar ichthyosis
phenylketonuria
primary hyperoxaluria type 1
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom