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The role of the calcium-sensing receptor in human disease.
[familial hypocalciuric hypercalcemia]
Following
the
discovery
of
the
calcium-sensing
receptor
(
CaSR
)
in
1993
,
its
pivotal
role
in
disorders
of
calcium
homeostasis
such
as
Familial
Hypocalciuric
Hypercalcemia
(
FHH
)
was
quickly
demonstrated
.
Since
then
,
it
has
become
clear
that
the
CaSR
has
immense
functional
versatility
largely
through
its
ability
to
activate
many
different
signaling
pathways
in
a
ligand-
and
tissue-
specific
manner
.
This
allows
the
receptor
to
play
diverse
and
crucial
roles
in
human
physiology
and
pathophysiology
,
both
in
calcium
homeostasis
and
in
tissues
and
biological
processes
unrelated
to
calcium
balance
.
This
review
covers
current
knowledge
of
the
role
of
the
CaSR
in
disorders
of
calcium
homeostasis
(
FHH
,
neonatal
severe
hyperparathyroidism
,
autosomal
dominant
hypocalcemia
,
primary
and
secondary
hyperparathyroidism
,
hypercalcemia
of
malignancy
)
as
well
as
unrelated
diseases
such
as
breast
and
colorectal
cancer
(
where
the
receptor
appears
to
play
a
tumor
suppressor
role
)
,
Alzheimer
's
disease
,
pancreatitis
,
diabetes
mellitus
,
hypertension
and
bone
and
gastrointestinal
disorders
.
In
addition
,
it
examines
the
use
or
potential
use
of
CaSR
agonists
or
antagonists
(
calcimimetics
and
calcilytics
)
and
other
drugs
mediated
through
the
CaSR
,
in
the
management
of
disorders
as
diverse
as
hyperparathyroidism
,
osteoporosis
and
gastrointestinal
disease
.
Diseases
Validation
Diseases presenting
"diabetes mellitus"
symptom
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
alpha-thalassemia
child syndrome
cholangiocarcinoma
cohen syndrome
congenital adrenal hyperplasia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cystinuria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
malignant atrophic papulosis
neuralgic amyotrophy
pyomyositis
sneddon syndrome
typhoid
werner syndrome
wolf-hirschhorn syndrome
This symptom has already been validated