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3-Nitrotyrosine as a biomarker for vascular involvement in Fabry disease.
[fabry disease]
Enzyme
replacement
therapy
in
Fabry
disease
was
initiated
in
2001
.
In
a
significant
proportion
of
patients
,
the
apparent
removal
of
stored
glycosphingolipid
from
the
endothelial
cells
does
not
prevent
progression
of
vascular
disease
.
Shu
et
al
.
show
a
link
between
accumulation
of
globotriaosylceramide
in
the
endothelial
cells
and
3
-
nitrotyrosine
formation
,
indicating
endothelial
nitric
oxide
synthase
uncoupling
.
3
-
Nitrotyrosine
will
be
useful
to
better
understand
Fabry
vasculopathy
,
and
to
evaluate
additional
therapeutic
interventions
targeting
oxidative
stress
.
Diseases
Validation
Diseases presenting
"additional therapeutic interventions"
symptom
fabry disease
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