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Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patients with esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
To
study
the
relationship
between
TLR
4
and
NF-κB
p
65
protein
expressions
in
tumor
tissues
after
radiotherapy
and
clinical
radiosensitivity
of
patients
with
esophageal
squamous
cell
carcinoma
.
A
total
of
93
patients
with
esophageal
squamous
cell
carcinoma
first
treated
in
our
hospital
by
radiotherapy
and
surgeries
from
November
2010
to
December
2013
were
selected
.
They
were
then
divided
into
a
severe
reaction
group
,
a
moderate
reaction
group
and
a
mild
reaction
group
according
to
the
postoperative
pathological
examination
results
of
tumor
tissues
.
The
expressions
of
TLR
4
and
NF-κB
p
65
in
the
tumor
samples
were
detected
by
Western
blotting
.
Compared
with
the
severe
reaction
group
,
the
expression
levels
of
TLR
4
and
NF-κB
p
65
in
the
moderate
reaction
group
significantly
increased
(
P
<
0
.
05
)
.
Similarly
,
the
expression
levels
of
the
mild
reaction
group
were
significantly
higher
than
those
of
the
moderate
reaction
group
(
P
<
0
.
05
)
.
Reducing
the
expression
levels
of
TLR
4
and
NF-κB
p
65
proteins
may
increase
the
radiosensitivity
of
patients
with
esophageal
cancer
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
