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Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patients with esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
To
study
the
relationship
between
TLR
4
and
NF-κB
p
65
protein
expressions
in
tumor
tissues
after
radiotherapy
and
clinical
radiosensitivity
of
patients
with
esophageal
squamous
cell
carcinoma
.
A
total
of
93
patients
with
esophageal
squamous
cell
carcinoma
first
treated
in
our
hospital
by
radiotherapy
and
surgeries
from
November
2010
to
December
2013
were
selected
.
They
were
then
divided
into
a
severe
reaction
group
,
a
moderate
reaction
group
and
a
mild
reaction
group
according
to
the
postoperative
pathological
examination
results
of
tumor
tissues
.
The
expressions
of
TLR
4
and
NF-κB
p
65
in
the
tumor
samples
were
detected
by
Western
blotting
.
Compared
with
the
severe
reaction
group
,
the
expression
levels
of
TLR
4
and
NF-κB
p
65
in
the
moderate
reaction
group
significantly
increased
(
P
<
0
.
05
)
.
Similarly
,
the
expression
levels
of
the
mild
reaction
group
were
significantly
higher
than
those
of
the
moderate
reaction
group
(
P
<
0
.
05
)
.
Reducing
the
expression
levels
of
TLR
4
and
NF-κB
p
65
proteins
may
increase
the
radiosensitivity
of
patients
with
esophageal
cancer
.
