Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Comparative analysis of histone H3 and H4 post-translational modifications of esophageal squamous cell carcinoma with different invasive capabilities.
[esophageal squamous cell carcinoma]
Eukaryotic
DNA
is
packaged
into
a
chromatin
with
the
help
of
four
core
histones
(
H
2
A
,
H
2
B
,
H
3
,
and
H
4
)
.
Diverse
histone
post-translational
modifications
(
PTMs
)
are
hence
involved
in
the
regulation
of
gene
transcription
.
However
,
how
this
regulation
does
work
is
still
poorly
understood
and
lacks
details
.
Here
we
used
the
mass
spectrometry-based
proteomics
approach
to
perform
a
comparative
analysis
of
histone
marks
at
a
global
level
in
two
phenotypes
of
esophageal
squamous
cell
carcinoma
(
ESCC
)
with
different
invasiveness
.
We
obtained
a
comprehensive
profiling
of
histone
H
3
and
H
4
PTMs
including
lysine
methylation
,
acetylation
and
novel
butyrylation
.
The
correlation
between
histone
marks
and
cancer
invasive
capabilities
was
further
characterized
and
one
distinguishable
PTM
,
H
4
K
79
me
2
was
discovered
and
verified
in
this
study
.
Immunohistochemistry
analysis
suggests
that
abnormal
level
of
H
4
K
79
me
2
may
be
related
to
poor
survival
of
ESCC
patients
.
Our
results
enrich
the
dataset
of
the
feature
pattern
of
global
histone
PTMs
in
ESCC
cell
lines
.
C
ore
histone
proteins
,
decorated
by
multiple
biological
significant
protein
post-translational
modifications
(
PTMs
)
such
as
lysine
acetylation
and
lysine
methylation
,
are
considered
to
regulate
gene
transcription
and
be
associated
with
the
development
of
cancer
.
Recent
studies
have
further
shown
that
global
level
of
histone
modifications
is
the
potential
hallmark
of
cancer
to
predict
the
clinical
outcomes
of
human
cancers
.
However
,
the
regulation
mechanism
is
largely
unknown
.
Here
we
used
the
mass
spectrometry
based
proteomics
coupled
with
stable
isotope
labeling
with
amino
acids
in
cell
culture
(
SILAC
)
to
characterize
the
global
levels
of
histone
marks
in
two
phenotypes
of
esophageal
squamous
cell
carcinoma
(
ESCC
)
cell
lines
with
different
invasive
capabilities
.
To
the
best
of
our
knowledge
,
it
is
the
first
report
about
the
comparative
analysis
for
histone
marks
of
the
different
invasive
ESCC
cell
lines
.
A
significantly
differential
level
of
histone
modification
,
H
4
K
79
me
2
,
was
determined
and
verified
.
Immunohistochemistry
analysis
further
suggests
that
abnormal
level
of
H
4
K
79
me
2
may
be
related
to
poor
survival
of
ESCC
patients
.
Our
results
could
contribute
to
understanding
the
different
expressions
of
global
histone
PTMs
in
different
invasive
ESCC
cell
lines
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
