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Esophageal squamous cell carcinoma with dural and bone marrow metastases.
[esophageal squamous cell carcinoma]
Patients
with
esophageal
squamous
cell
carcinoma
generally
present
at
an
advanced
stage
at
the
time
of
diagnosis
.
The
most
common
sites
of
visceral
metastasis
are
the
lung
,
liver
and
bone
,
but
brain
and
bone
marrow
involvement
is
exceedingly
rare
.
Herein
,
we
report
a
62
-
year
-old
man
with
a
4
-
wk
history
of
progressive
low
back
pain
with
radiation
to
bilateral
lower
legs
,
dysphagia
and
body
weight
loss
.
Esophageal
squamous
cell
carcinoma
with
regional
lymph
node
,
liver
and
bone
metastases
was
diagnosed
.
He
underwent
concurrent
chemoradiotherapy
and
got
a
partial
response
.
Four
months
later
,
he
complained
of
headache
,
diplopia
and
severe
hearing
impairment
in
the
left
ear
.
There
was
no
evidence
for
bacterial
,
fungal
,
tuberculous
infection
or
neoplastic
infiltration
.
Magnetic
resonance
imaging
of
the
brain
demonstrated
thickening
and
enhancement
of
bilateral
pachymeninges
and
multiple
enhancing
masses
in
bilateral
skull
.
Dural
metastasis
was
diagnosed
and
he
received
whole
brain
irradiation
.
In
addition
,
laboratory
examination
revealed
severe
thrombocytopenia
and
leucopenia
,
and
bone
marrow
study
confirmed
the
diagnosis
of
metastatic
squamous
cell
carcinoma
.
This
is
the
first
described
case
of
esophageal
squamous
cell
carcinoma
with
dural
and
bone
marrow
metastases
.
We
also
discuss
the
pathogenesis
of
unusual
metastatic
diseases
and
differential
diagnosis
of
pachymeningeal
thickening
.
Diseases
Validation
Diseases presenting
"dysphagia"
symptom
alexander disease
cadasil
cushing syndrome
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
inclusion body myositis
kindler syndrome
liposarcoma
locked-in syndrome
neuralgic amyotrophy
oligodontia
triple a syndrome
well-differentiated liposarcoma
This symptom has already been validated