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The modified glasgow prognostic score is an independent prognostic factor in patients with inoperable thoracic esophageal squamous cell carcinoma undergoing chemoradiotherapy.
[esophageal squamous cell carcinoma]
There
is
increasing
evidence
that
the
presence
of
an
inflammation
-based
prognostic
score
(
modified
Glasgow
prognostic
score
,
mGPS
)
is
associated
with
survival
in
patients
with
advanced
cancer
.
This
study
aimed
to
assess
whether
the
mGPS
has
prognostic
value
in
patients
with
thoracic
esophageal
squamous
cell
carcinoma
undergoing
chemoradiotherapy
.
A
total
of
212
patients
undergoing
chemoradiotherapy
for
newly-diagnosed
esophageal
squamous
cell
carcinoma
between
October
,
2006
and
December
,
2011
were
retrospectively
analyzed
.
Serum
C-
reactive
protein
(
CRP
)
and
albumin
were
measured
before
initiation
of
treatment
.
The
relationships
between
the
mGPS
and
other
relevant
variables
including
white
blood
cell
count
,
neutrophilic
granulocyte
count
,
platelet
count
,
hemoglobin
,
bilirubin
,
aspartate
aminotransferase
(
AST
)
,
alanine
aminotransferase
(
ALT
)
and
lactate
dehydrogenase
(
LDH
)
were
analyzed
.
Overall
survival
(
OS
)
and
progression-free
survival
(
PFS
)
were
calculated
.
Significant
prognostic
factors
were
identified
using
univariate
and
multivariate
analyses
.
Three
-
year
OS
for
all
patients
was
24
.
6
%
;
3
-
year
PFS
was
21
.
3
%
.
Patients
with
a
mGPS
of
0
,
1
and
2
were
90
,
78
,
44
,
respectively
.
Higher
mGPS
was
related
to
higher
white
blood
cell
,
neutrophilic
granulocyte
and
platelet
counts
,
and
lower
total
bilirubin
.
T
stage
,
M
stage
and
mGPS
were
independent
prognostic
indicators
for
OS
;
T
stage
,
M
stage
,
mGPS
and
platelet
count
were
independent
prognostic
indicators
for
PFS
.
Pretreatment
mGPS
is
an
easily
measurable
significant
prognostic
factor
and
can
be
used
in
combination
with
conventional
TNM
staging
to
predict
survival
in
patients
with
squamous
cell
carcinoma
undergoing
chemoradiotherapy
.
Diseases
Validation
Diseases presenting
"neutrophilic granulocyte count"
symptom
esophageal squamous cell carcinoma
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