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Downregulation of MLL3 in esophageal squamous cell carcinoma is required for the growth and metastasis of cancer cells.
[esophageal squamous cell carcinoma]
The
mixed
lineage
leukemia
3
(
MLL
3
)
,
a
member
of
the
mixed
lineage
leukemia
(
MLL
)
family
,
has
been
reported
to
be
mutated
in
multiple
cancer
types
.
However
,
its
function
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
poorly
understood
.
Here
,
we
found
that
the
expression
of
MLL
3
was
downregulated
in
ESCC
tissues
.
Moreover
,
over-expression
of
MLL
3
in
ESCC
cells
inhibited
cell
proliferation
and
migration
,
while
the
knockdown
expression
of
MLL
3
promoted
the
tumorigenicity
of
ESCC
cells
.
Mechanistically
,
MLL
3
regulated
the
expression
of
multiple
growth
-related
and
migration-related
genes
.
Taken
together
,
our
study
suggested
that
downregulation
of
MLL
3
was
very
important
in
the
progression
of
ESCC
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
