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Downregulation of MLL3 in esophageal squamous cell carcinoma is required for the growth and metastasis of cancer cells.
[esophageal squamous cell carcinoma]
The
mixed
lineage
leukemia
3
(
MLL
3
)
,
a
member
of
the
mixed
lineage
leukemia
(
MLL
)
family
,
has
been
reported
to
be
mutated
in
multiple
cancer
types
.
However
,
its
function
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
poorly
understood
.
Here
,
we
found
that
the
expression
of
MLL
3
was
downregulated
in
ESCC
tissues
.
Moreover
,
over-expression
of
MLL
3
in
ESCC
cells
inhibited
cell
proliferation
and
migration
,
while
the
knockdown
expression
of
MLL
3
promoted
the
tumorigenicity
of
ESCC
cells
.
Mechanistically
,
MLL
3
regulated
the
expression
of
multiple
growth
-related
and
migration-related
genes
.
Taken
together
,
our
study
suggested
that
downregulation
of
MLL
3
was
very
important
in
the
progression
of
ESCC
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated