Association between glutathione S-transferases P1 Ile105Val polymorphism and susceptibility to esophageal cancer: evidence from 20 case-control studies.

[esophageal squamous cell carcinoma]

Available epidemiological studies had estimated the correlation between glutathione S-transferases P 1 (GSTP 1 ) Ile 105 V al polymorphism and esophageal cancer (EC ) risk . However , the conclusions were controversial and inconclusive . An updated meta -analysis was conducted to explore whether GSTP 1 polymorphism could be contributed to the EC risk . Ultimately , a total of 2 ,992 cases and 4 ,758 controls from 20 previous studies were included . Crude odds ratios (ORs ) with 95 % confidence intervals (95 % CIs ) were used to assess the strength of the associations . Pooled results suggested that GSTP 1 Ile 105 V al polymorphism significantly increased the risk of developing EC in Caucasians under three genetic models (G vs . A , OR 1 .146 , 95 % CI 1 .031 -1 .275 , P = 0 .012 , I (2 ) = 30 .40 %; GA vs . AA , OR 1 .208 , 95 % CI 1 .036 -1 .408 , P = 0 .016 , I (2 ) = 50 .30 %; GG +GA vs . AA , OR 1 .219 , 95 % CI 1 .053 -1 .410 , P = 0 .008 , I (2 ) = 44 .50 %). However , no significant correlation was found in Asians , African and mixed ethnicities analyses . Moreover , similar results were detected for any genetic model in esophageal squamous cell carcinoma and esophageal adenocarcinoma when stratifying for pathologic types . This meta -analysis provides new evidences that GSTP 1 Ile 105 Val gene polymorphism contributes to EC susceptibility in Caucasians .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated