Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Genome wide screening and characterization of long non-coding RNAs in esophageal cancer].
[esophageal squamous cell carcinoma]
To
screen
for
esophageal
squamous
cell
carcinoma
(
ESCC
)
-
associated
long
non-coding
RNAs
(
lncRNA
)
and
identify
oncogenic
lncRNA
contributing
to
ESCC
pathogenesis
.
A
lncRNA
array
containing
7419
lncRNA
was
used
to
detect
the
transcriptional
profiles
of
lncRNA
of
four
pairs
of
ESCC
and
matched
normal
esophageal
tissue
.
Bioinformatic
analysis
was
employed
to
identify
differentially
expressed
ESCC
associated
lncRNA
(
ESCCAL
)
.
Quantitative
real-time
PCR
was
used
to
verify
selected
dysregulated
lncRNA
on
independent
ESCC
samples
.
Genome-
wide
transcriptome
profiling
(
coding
and
or
noncoding
RNA
transcripts
)
was
able
to
distinguish
ESCC
from
normal
tissue
.
Among
these
,
bioinformatic
analysis
has
identified
154
differentially
expressed
ESCC
associated
lncRNA
(
ESCCALs
)
,
which
included
111
downregulated
and
43
upregulated
lncRNA
in
ESCC
relative
to
the
normal
tissue
(
P
<
0
.
01
)
.
The
highest
upregulated
lncRNA
(
ESCCAL
_
1
)
and
known
onco-lnc
RNA
HOTAIR
was
further
verified
in
26
paired
ESCC
samples
.
ESCCAL
_
1
and
HOTAIR
were
found
to
be
highly
expressed
in
17
ESCC
and
18
ESCC
compared
with
normal
esophageal
tissues
.
This
investigation
has
revealed
large
scale
aberrant
expression
of
lncRNA
in
ESCC
.
About
70
%
of
novel
lncRNA-ESCCAL
_
1
,
together
with
a
known
lncRNA-HOTAIR
,
are
highly
expressed
in
ESSC
,
suggesting
that
ESCCAL
_
1
and
HOTAIR
may
participate
in
the
pathological
process
of
ESCC
.
Furthermore
,
lncRNA
could
be
potential
diagnostic
and
prognostic
biomarkers
for
ESCC
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated