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Clinical outcome of photodynamic therapy in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
The
aim
of
this
study
was
to
evaluate
the
feasibility
and
safety
of
photodynamic
therapy
(
PDT
)
as
a
curative
treatment
option
or
as
palliative
therapy
for
esophageal
squamous
cell
carcinoma
.
Medical
records
of
patients
who
received
PDT
for
esophageal
squamous
cell
carcinoma
,
including
carcinoma
in
situ
,
were
reviewed
retrospectively
.
Survival
analysis
was
performed
using
the
Kaplan-
Meier
method
.
A
total
of
31
cases
were
treated
with
PDT
between
2003
and
2013
.
Treatment
was
for
palliative
purposes
in
11
cases
(
35
.
5
%
)
and
for
therapeutic
purposes
in
20
cases
(
64
.
5
%
)
.
We
achieved
15
cases
(
48
.
4
%
)
of
complete
remission
and
16
(
51
.
6
%
)
cases
of
partial
remission
during
the
follow-up
period
.
There
were
6
fatalities
,
5
of
which
were
related
to
disease
progression
.
Complications
,
including
benign
strictures
,
occurred
in
11
cases
(
35
.
5
%
)
but
there
was
only
1
complication-related
death
.
Recurrence
occurred
in
2
patients
with
complete
remission
.
Overall
survival
was
31
.
9
months
for
patients
with
complete
remission
and
28
.
2
months
for
those
with
partial
remission
.
Disease-free
survival
of
patients
with
complete
remission
was
21
.
9
months
.
Our
data
suggest
that
photodynamic
therapy
is
a
reasonable
palliative
treatment
option
with
acceptable
complication
rates
for
esophageal
cancer
and
could
be
performed
for
therapeutic
purposes
in
cases
of
early
esophageal
cancer
.
