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High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinoma.
[esophageal squamous cell carcinoma]
Long
non-coding
RNAs
(
lncRNAs
)
play
a
key
role
in
cellular
processes
,
such
as
cell
growth
,
apoptosis
,
and
carcinogenesis
.
lncRNAs
SPRY
4
-
IT
1
has
recently
been
identified
to
be
involved
in
tumorigenesis
of
several
cancers
such
as
non-
small
cell
lung
cancer
and
esophageal
squamous
cell
carcinoma
.
However
,
the
role
of
SPRY
4
-
IT
1
in
clear
cell
renal
cell
carcinoma
(
ccRCC
)
remains
unclear
.
The
expression
of
SPRY
4
-
IT
1
was
examined
in
ccRCC
patients
and
renal
cancer
cell
lines
by
using
quantitative
real-time
PCR
(
qRT-PCR
)
.
The
relationship
between
SPRY
4
-
IT
1
level
and
clinicopathological
parameters
of
ccRCC
was
analyzed
with
the
Kaplan-
Meier
method
and
Cox
proportional
hazards
model
.
Small
interfering
RNA
(
siRNA
)
was
used
to
suppress
SPRY
4
-
IT
1
expression
in
renal
cancer
cell
line
786
-
O
.
In
vitro
assays
were
performed
to
further
explore
its
role
in
renal
cancer
progressio
.
The
relative
level
of
SPRY
4
-
IT
1
was
significantly
higher
in
ccRCC
tissues
compared
to
the
adjacent
normal
renal
tissues
.
And
higher
expression
of
SPRY
4
-
IT
1
was
found
in
renal
cancer
cell
lines
compared
with
the
normal
human
proximal
tubule
epithelial
cell
line
HK
-
2
.
The
ccRCC
patients
with
higher
SPRY
4
-
IT
1
expression
had
an
advanced
clinical
stage
and
poorer
prognosis
than
those
with
lower
SPRY
4
-
IT
1
expression
.
Multivariate
analyses
by
Cox
's
proportional
hazard
model
revealed
that
expression
of
SPRY
4
-
IT
1
was
an
independent
prognostic
factor
in
ccRCC
.
In
vitro
assays
,
our
results
indicated
that
knockdown
of
SPRY
4
-
IT
1
reduced
renal
cancer
cell
proliferation
,
migration
,
and
invasion
.
Our
data
suggested
that
lncRNA
SPRY
4
-
IT
1
might
be
considered
as
a
potential
prognostic
indicator
and
a
potential
target
for
therapeutic
intervention
in
RC
.
Diseases
Validation
Diseases presenting
"a potential target for therapeutic intervention in rc"
symptom
esophageal squamous cell carcinoma
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