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A four actin-binding protein signature model for poor prognosis of patients with esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
The
actin
cytoskeleton
is
a
dynamic
structure
with
actin-binding
proteins
(
ABPs
)
playing
an
essential
role
in
the
regulation
of
migration
,
differentiation
and
signal
transduction
in
all
eukaryotic
cells
.
We
examined
the
relationship
between
altered
expression
of
four
ABPs
and
clinical
parameters
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
To
this
end
,
we
analyzed
152
formalin-fixed
and
paraffin-embedded
esophageal
curative
resection
specimens
by
immunohistochemistry
for
tensin
,
profilin-
1
,
villin-
1
and
talin
.
A
molecular
predictor
model
,
based
on
the
combined
expression
of
the
four
proteins
,
was
developed
to
correlate
the
expression
pattern
of
the
four
ABPs
with
clinical
factors
and
prognosis
of
ESCC
.
According
to
the
results
,
weak
significance
was
found
for
tensin
in
lymph
node
metastasis
(
P
=
0
.
033
)
,
and
profilin-
1
in
pTNM
stage
(
P
=
0
.
031
)
.
However
,
our
four
-protein
model
showed
strong
correlation
with
the
5
-
year
overall
survival
rate
(
P
=
0
.
002
)
.
Similarly
,
Kendall
's
tau-
b
test
also
showed
the
relationship
between
the
collective
expression
pattern
of
the
four
ABPs
with
lymph
node
metastasis
(
P
=
0
.
005
)
and
pTNM
stage
(
P
=
0
.
001
)
.
Our
results
demonstrate
that
the
collective
protein
expression
pattern
of
four
actin-binding
proteins
could
be
a
biomarker
to
estimate
the
prognosis
of
ESCC
patients
.
Diseases
Validation
Diseases presenting
"combined expression of the four proteins"
symptom
esophageal squamous cell carcinoma
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