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The impact of pri-miR-218 rs11134527 on the risk and prognosis of patients with esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
MicroRNA-
218
(
miR-
218
)
acts
as
a
tumor
suppressor
in
numerous
types
of
cancer
by
regulation
of
the
expression
of
target
genes
.
The
aim
of
this
study
was
to
investigate
whether
polymorphisms
in
miR-
218
LAMB
3
pathway
were
associated
with
the
risk
and
prognosis
of
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
Pri-mir-
218
rs
11134527
and
LAMB
3
rs
2566
were
genotyped
in
ESCC
patients
and
745
controls
to
assess
their
associations
with
cancer
risk
and
overall
survival
.
Pri-mir-
218
rs
11134527
was
significantly
associated
with
a
decreased
risk
of
ESCC
under
codominant
,
recessive
and
additive
models
.
Although
there
was
a
significant
association
between
rs
11134527
and
better
survival
of
ESCC
patients
under
codominant
,
recessive
and
additive
models
,
the
association
disappeared
after
adjustment
for
TNM
and
LNM
.
However
,
further
stratified
analysis
revealed
that
the
association
remained
significant
in
patients
with
TNM
stages
I
and
II
or
non-
LNM
.
Our
data
suggest
that
pri-mi
R-
218
rs
11134527
may
contribute
to
the
genetic
susceptibility
and
prognosis
for
ESCC
in
Chinese
Han
population
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated