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Up-regulation of miR-335 predicts a favorable prognosis in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
MicroRNAs
(
miRNAs
)
are
noncoding
RNAs
that
regulate
multiple
cellular
processes
during
cancer
progression
.
MiR-
335
has
recently
been
identified
to
be
involved
in
tumorigenesis
of
several
cancers
such
as
ovarian
cancer
and
gastric
cancer
.
However
,
the
regulation
of
miR-
335
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
has
not
been
reported
yet
.
Expression
of
miR-
335
in
tumor
and
their
normal
matched
tissues
was
determined
by
quantitative
real-time
PCR
in
67
ESCC
patients
and
its
association
with
overall
survival
of
patients
was
analyzed
by
statistical
analysis
.
The
expression
level
of
miR-
335
was
reduced
in
malignant
tissue
samples
in
comparison
to
normal
matched
tissue
(
P
<
0
.
05
)
.
It
was
also
proved
that
miR-
335
expression
was
associated
with
ESCC
histological
grade
,
lymph
node
metastasis
,
tumor
stage
and
clinical
stage
(
P
<
0
.
05
)
.
In
addition
,
the
Kaplan-
Meier
survival
curves
revealed
that
low
miR-
335
expression
was
associated
with
poor
prognosis
in
ESCC
patients
.
Multivariate
analysis
showed
that
miR-
335
expression
was
an
independent
prognostic
marker
of
overall
survival
of
ESCC
patients
.
The
study
proves
for
the
first
time
that
miR-
335
is
down
regulated
in
a
majority
of
ESCC
patients
.
Our
results
indicate
that
miR-
335
expression
is
an
independent
prognostic
factor
for
patients
with
esophageal
cancer
,
which
might
be
a
potential
valuable
biomarker
for
ESCC
.
Diseases
Validation
Diseases presenting
"independent prognostic marker"
symptom
carcinoma of the gallbladder
esophageal squamous cell carcinoma
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