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Second-line docetaxel-based chemotherapy after failure of fluorouracil-based first-line treatment for advanced esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
This
retrospective
analysis
evaluates
the
clinical
efficacy
and
toxicity
of
second
-line
docetaxel-based
chemotherapy
after
failure
of
fluorouracil-based
first
-line
treatment
for
advanced
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
We
retrospectively
reviewed
patients
who
had
received
second
-line
docetaxel-based
chemotherapy
for
advanced
ESCC
in
Zhejiang
Cancer
Hospital
between
January
2008
and
December
2011
.
Survival
curves
were
plotted
using
the
Kaplan-
Meier
method
.
The
Cox
proportional
hazard
model
was
used
for
multivariate
analysis
.
Eighty
-
five
patients
received
docetaxel-based
second
-line
chemotherapy
after
the
failure
of
first
-line
fluorouracil-based
treatment
.
Forty
-
four
patients
received
docetaxel-platinum
chemotherapy
,
and
41
received
docetaxel
single
-
agent
treatment
.
The
progression-free
survival
(
PFS
)
and
overall
survival
(
OS
)
were
3
.
5
and
5
.
5
months
in
all
of
the
patients
,
respectively
.
There
were
no
statistically
significant
differences
in
PFS
and
OS
between
docetaxel-platinum
and
docetaxel
single
-
agent
chemotherapy
groups
(
P-
value
0
.
38
and
0
.
64
,
respectively
)
.
Response
to
first
-line
chemotherapy
was
a
favorable
prognostic
factor
for
PFS
in
uni-
and
multivariate
analyses
(
P-
value
0
.
005
and
0
.
028
,
respectively
)
.
Patients
with
docetaxel-based
second
-line
treatment
obtained
a
moderate
PFS
advantage
in
advanced
ESCC
.
Response
to
first
-line
chemotherapy
was
a
favorable
prognostic
factor
for
PFS
of
second
-line
chemotherapy
in
advanced
ESCC
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated