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Downregulation of VGLL4 in the progression of esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
VGLL
4
,
a
member
of
the
Vestigial-like
(
VGLL
)
proteins
,
has
been
reported
to
be
dysregulated
in
several
cancer
types
.
However
,
its
function
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
poorly
understood
.
Here
,
it
was
found
that
the
expression
level
of
VGLL
4
was
decreased
in
ESCC
tissues
.
Moreover
,
forced
expression
of
VGLL
4
in
ESCC
cells
inhibited
cell
growth
and
migration
,
while
knockdown
of
VGLL
4
expression
promoted
the
tumorigenecity
of
ESCC
cells
.
Mechanistically
,
VGLL
4
regulated
the
growth
and
motility
of
ESCC
cells
through
downregulating
the
expression
of
connective
tissue
growth
factor
(
CTGF
)
,
a
known
oncogene
in
the
progression
of
ESCC
.
Taken
together
,
our
study
suggested
that
downregulation
of
VGLL
4
was
very
important
in
the
progression
of
ESCC
,
and
restoring
the
function
of
VGLL
4
might
be
a
promising
therapeutic
strategy
for
ESCC
.
Diseases
Validation
Diseases presenting
"growth factor"
symptom
22q11.2 deletion syndrome
achondroplasia
adrenal incidentaloma
aniridia
cadasil
cholangiocarcinoma
coats disease
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dystrophic epidermolysis bullosa
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
holt-oram syndrome
inclusion body myositis
kallmann syndrome
krabbe disease
liposarcoma
lymphangioleiomyomatosis
oculocutaneous albinism
oral submucous fibrosis
pleomorphic liposarcoma
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
systemic capillary leak syndrome
von hippel-lindau disease
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
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