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Downregulation of VGLL4 in the progression of esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
VGLL
4
,
a
member
of
the
Vestigial-like
(
VGLL
)
proteins
,
has
been
reported
to
be
dysregulated
in
several
cancer
types
.
However
,
its
function
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
poorly
understood
.
Here
,
it
was
found
that
the
expression
level
of
VGLL
4
was
decreased
in
ESCC
tissues
.
Moreover
,
forced
expression
of
VGLL
4
in
ESCC
cells
inhibited
cell
growth
and
migration
,
while
knockdown
of
VGLL
4
expression
promoted
the
tumorigenecity
of
ESCC
cells
.
Mechanistically
,
VGLL
4
regulated
the
growth
and
motility
of
ESCC
cells
through
downregulating
the
expression
of
connective
tissue
growth
factor
(
CTGF
)
,
a
known
oncogene
in
the
progression
of
ESCC
.
Taken
together
,
our
study
suggested
that
downregulation
of
VGLL
4
was
very
important
in
the
progression
of
ESCC
,
and
restoring
the
function
of
VGLL
4
might
be
a
promising
therapeutic
strategy
for
ESCC
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
