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Downregulation of VGLL4 in the progression of esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
VGLL
4
,
a
member
of
the
Vestigial-like
(
VGLL
)
proteins
,
has
been
reported
to
be
dysregulated
in
several
cancer
types
.
However
,
its
function
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
poorly
understood
.
Here
,
it
was
found
that
the
expression
level
of
VGLL
4
was
decreased
in
ESCC
tissues
.
Moreover
,
forced
expression
of
VGLL
4
in
ESCC
cells
inhibited
cell
growth
and
migration
,
while
knockdown
of
VGLL
4
expression
promoted
the
tumorigenecity
of
ESCC
cells
.
Mechanistically
,
VGLL
4
regulated
the
growth
and
motility
of
ESCC
cells
through
downregulating
the
expression
of
connective
tissue
growth
factor
(
CTGF
)
,
a
known
oncogene
in
the
progression
of
ESCC
.
Taken
together
,
our
study
suggested
that
downregulation
of
VGLL
4
was
very
important
in
the
progression
of
ESCC
,
and
restoring
the
function
of
VGLL
4
might
be
a
promising
therapeutic
strategy
for
ESCC
.
Diseases
Validation
Diseases presenting
"promising therapeutic strategy"
symptom
esophageal squamous cell carcinoma
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