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The clinical and biological significance of STAT1 in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
Loss
of
STAT
1
(
Signal
Transducer
and
Activator
of
Transcription-
1
)
has
been
implicated
in
the
pathobiology
of
a
number
of
cancer
types
.
Nonetheless
,
the
biological
and
clinical
significance
of
STAT
1
in
esophageal
squamous
cell
carcinomas
(
ESCC
)
has
not
been
comprehensively
studied
.
Using
immunohistochemistry
,
we
detected
the
STAT
1
expression
in
a
cohort
of
ESCC
patients
;
In-vitro
experiments
,
we
used
enforced
gene
transfection
of
STAT
1
C
into
two
STAT
1
-
weak
/
negative
ESCC
cell
lines
and
siRNA
knockdown
of
STAT
1
in
two
STAT
1
-
strong
ESCC
cell
lines
to
detect
STAT
1
function
in
ESCC
.
We
found
that
the
expression
of
STAT
1
was
heterogeneous
in
ESCC
,
with
64
(
49
.
0
%
)
strongly
positive
cases
,
59
(
45
.
0
%
)
weakly
positive
cases
and
8
(
6
.
1
%
)
negative
cases
.
STAT
1
expression
inversely
correlated
with
the
depth
of
tumor
invasion
and
tumor
size
(
p
=
0
.
047
and
p
=
0
.
029
,
respectively
,
Chi
square
)
.
Furthermore
,
patients
with
STAT
1
-
strong
/
weak
tumors
had
a
significantly
longer
survival
compared
to
those
with
STAT
1
-
negative
tumors
(
33
.
6
months
versus
13
.
1
months
,
p
=
0
.
019
)
.
In
patients
carrying
tumors
of
aggressive
cytology
(
n
=
50
)
,
those
with
STAT
1
-
strong
tumors
survived
significantly
longer
than
those
with
STAT
1
-
weak
/
negative
tumors
(
34
.
6
months
versus
20
.
5
months
,
p
=
0
.
011
)
.
Our
in
-vitro
experiments
revealed
that
STAT
1
is
proapoptotic
and
inhibitory
to
cell-cycle
progression
and
colony
formation
.
Lastly
,
we
found
evidence
that
STAT
1
signaling
in
ESCC
cells
down-regulated
the
expression
and
/
or
activity
of
NF-κB
and
STAT
3
,
both
of
which
are
known
to
have
oncogenic
potential
.
To
conclude
,
our
findings
suggest
that
STAT
1
is
a
tumor
suppressor
in
ESCC
.
Loss
of
STAT
1
,
which
is
frequent
in
ESCC
,
contributes
to
the
pathogenesis
of
these
tumors
.
Diseases
Validation
Diseases presenting
"8"
symptom
acute rheumatic fever
cystinuria
esophageal squamous cell carcinoma
hirschsprung disease
megacystis-microcolon-intestinal hypoperistalsis syndrome
scrub typhus
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