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The clinical and biological significance of STAT1 in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
Loss
of
STAT
1
(
Signal
Transducer
and
Activator
of
Transcription-
1
)
has
been
implicated
in
the
pathobiology
of
a
number
of
cancer
types
.
Nonetheless
,
the
biological
and
clinical
significance
of
STAT
1
in
esophageal
squamous
cell
carcinomas
(
ESCC
)
has
not
been
comprehensively
studied
.
Using
immunohistochemistry
,
we
detected
the
STAT
1
expression
in
a
cohort
of
ESCC
patients
;
In-vitro
experiments
,
we
used
enforced
gene
transfection
of
STAT
1
C
into
two
STAT
1
-
weak
/
negative
ESCC
cell
lines
and
siRNA
knockdown
of
STAT
1
in
two
STAT
1
-
strong
ESCC
cell
lines
to
detect
STAT
1
function
in
ESCC
.
We
found
that
the
expression
of
STAT
1
was
heterogeneous
in
ESCC
,
with
64
(
49
.
0
%
)
strongly
positive
cases
,
59
(
45
.
0
%
)
weakly
positive
cases
and
8
(
6
.
1
%
)
negative
cases
.
STAT
1
expression
inversely
correlated
with
the
depth
of
tumor
invasion
and
tumor
size
(
p
=
0
.
047
and
p
=
0
.
029
,
respectively
,
Chi
square
)
.
Furthermore
,
patients
with
STAT
1
-
strong
/
weak
tumors
had
a
significantly
longer
survival
compared
to
those
with
STAT
1
-
negative
tumors
(
33
.
6
months
versus
13
.
1
months
,
p
=
0
.
019
)
.
In
patients
carrying
tumors
of
aggressive
cytology
(
n
=
50
)
,
those
with
STAT
1
-
strong
tumors
survived
significantly
longer
than
those
with
STAT
1
-
weak
/
negative
tumors
(
34
.
6
months
versus
20
.
5
months
,
p
=
0
.
011
)
.
Our
in
-vitro
experiments
revealed
that
STAT
1
is
proapoptotic
and
inhibitory
to
cell-cycle
progression
and
colony
formation
.
Lastly
,
we
found
evidence
that
STAT
1
signaling
in
ESCC
cells
down-regulated
the
expression
and
/
or
activity
of
NF-κB
and
STAT
3
,
both
of
which
are
known
to
have
oncogenic
potential
.
To
conclude
,
our
findings
suggest
that
STAT
1
is
a
tumor
suppressor
in
ESCC
.
Loss
of
STAT
1
,
which
is
frequent
in
ESCC
,
contributes
to
the
pathogenesis
of
these
tumors
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
