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Notch Signaling Target Genes are Directly Correlated to Esophageal Squamous Cell Carcinoma Tumorigenesis.
[esophageal squamous cell carcinoma]
Notch
signaling
is
an
important
cellular
pathway
which
affects
the
development
and
function
of
many
organs
.
It
plays
critical
roles
in
maintaining
of
progenitor
stem
cell
population
as
well
as
balancing
cell
proliferation
,
survival
,
differentiation
and
apoptosis
.
It
has
been
shown
that
notch
signaling
is
aberrantly
activated
during
the
carcinogenesis
of
a
variety
of
human
cancers
.
In
this
study
we
aimed
to
explore
activation
of
this
signaling
pathway
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
through
expressional
analysis
of
notch
signaling
target
genes
.
The
mRNA
expression
of
HEY
1
and
HEY
2
was
comparatively
analyzed
by
real-time
PCR
in
tumor
and
related
margin
normal
tissues
of
50
ESCC
patients
.
Comparative
quantitative
real-time
PCR
indicates
the
overexpression
of
HEY
1
and
HEY
2
in
54
and
30
%
of
ESCC
samples
,
respectively
.
Overexpression
of
HEY
1
was
significantly
associated
with
stage
of
the
tumor
(
p
=
0
.
048
)
and
tumor
location
(
p
=
0
.
008
)
.
HEY
2
overexpression
was
also
significantly
correlated
to
node
metastasis
of
tumor
cells
(
p
=
0
.
043
)
.
Overexpression
of
HEY
1
and
HEY
2
in
ESCC
is
correlated
to
different
indices
of
poor
prognosis
and
it
is
extrapolated
that
such
overexpression
is
important
in
progression
and
development
of
ESCC
tumorigenesis
.
To
the
best
of
our
knowledge
,
this
is
the
first
report
introducing
aberrant
activation
of
notch
signaling
target
genes
in
ESCC
,
where
it
plays
roles
in
development
and
progression
of
the
malignancy
and
may
be
considered
in
therapeutic
modalities
to
restrict
ESCC
progression
.
Diseases
Validation
Diseases presenting
"first report"
symptom
achondroplasia
alexander disease
aniridia
cadasil
canavan disease
child syndrome
cohen syndrome
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
dedifferentiated liposarcoma
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
focal myositis
harlequin ichthyosis
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
homocystinuria without methylmalonic aciduria
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kindler syndrome
krabbe disease
lamellar ichthyosis
liposarcoma
lymphangioleiomyomatosis
monosomy 21
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
pendred syndrome
pleomorphic liposarcoma
primary hyperoxaluria type 1
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
werner syndrome
wiskott-aldrich syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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