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A novel human interleukin-24 peptide created by computer-guided design contributes to suppression of proliferation in esophageal squamous cell carcinoma Eca-109 cells.
[esophageal squamous cell carcinoma]
Based
on
the
three
-dimensional
modeling
structure
of
human
interleukin-
24
(
hIL-
24
)
and
its
most
likely
active
position
predicted
by
solvent
accessibility
and
apparent
electrostatic
properties
,
a
novel
hIL-
24
peptide
M
1
was
created
by
computer-guided
molecular
design
.
The
cytotoxicity
and
cell
selectivity
of
M
1
were
examined
in
three
human
carcinoma
cell
lines
and
one
normal
human
embryo
lung
fibroblast
cell
line
(
HEL
)
.
MTT
assay
showed
that
M
1
induced
growth
arrest
in
two
IL
-
20
receptor
complex
-
positive
cancer
cell
lines
(
the
esophageal
squamous
cell
carcinoma
cell
line
Eca-
109
and
the
melanoma
cell
line
A
375
)
,
and
antibodies
against
IL
-
24
or
IL
-
20
receptor
complexes
significantly
neutralized
the
inhibitory
activity
.
Moreover
,
M
1
had
almost
no
cytotoxicity
on
the
lung
cancer
A
549
cell
line
,
which
lacks
a
full
complement
of
the
IL
-
20
receptor
complexes
,
or
on
HEL
cells
that
express
the
IL
-
20
receptor
complexes
.
These
findings
demonstrate
that
M
1
could
act
as
an
excellent
candidate
for
the
induction
of
growth
arrest
on
receptor
complex
-
positive
cancer
cells
.
In
summary
,
the
M
1
peptide
may
represent
a
novel
anticancer
agent
for
esophageal
squamous
cell
carcinoma
therapy
due
to
its
cancer
cell
selectivity
and
its
relatively
low
cytotoxicity
to
normal
cells
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated